Cardiovascular Bioengineering Lab
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Cardiovascular Flow

Non-physiological flow patterns influence hemostasis by chronically activating platelets, which can lead to hemolysis, platelet destruction and thromboembolism. Platelets are activated by high shear stress like those experienced in the housing gaps of medical devices such as mechanical heart valves and heart pumps.  The level of platelet activation is proportionally related to the time exposure, accumulating with repeated exposures. Flow-induced shear platelet activation causes both platelet aggregation and thrombin generation with high potential for thromboembolism and stroke. 
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Intraventricular flow in the DCM model                                                         Intraventricular flow with high LVAD support
Flow velocity within the left ventricle is studied in a mock circulatory loop using an engineering method of flow visualization known as particle image velocimetry (PIV).  The high SNR of this method enables high spatial resolution and subsequent analysis of vortex formation, kinetic energy, residence time and transport for a wide range of clinically relevant conditions.
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  • Home
  • Research
    • Cardiac Flow
    • Valve Biomechanics
    • Tissue Mechanics
    • Mechanobiology
  • Our Team
  • Publications
  • Capabilities
  • Outreach
  • Big Ideas